Chairperson: Frank A. Pintar, Ph.D.
Biomedical Engineering Graduate Programs website

Degrees Offered

Master of Science, Master of Engineering; Doctor of Philosophy
Medical Scientist Training Program (M.D./Ph.D.) - MCW only

Mission Statement

The Marquette University (MU) and Medical College of Wisconsin (MCW) Department of Biomedical Engineering is dedicated to delivering an extraordinary educational experience designed to empower the next generation of biomedical engineers, scientists and physicians. If you have a passion for learning and a desire to translate ideas into action — particularly those involving medical devices and health care technologies — let our facultystaff and industry partners guide you on your journey. We develop leaders and problem solvers skilled at applying engineering, science and design principles to improve health in the service of humanity by:

  • Discovering and disseminating new knowledge;
  • Promoting critical thinking and lifelong learning;
  • Guiding students to meaningful and ethical professional and personal lives;
  • Fostering interdisciplinary and collaborative research and education through academic and industrial alliances;
  • Continuing innovative leadership in education, research and industrial relationships; and
  • Inspiring faculty and students to serve others.

Program Descriptions

The MU-MCW biomedical engineering program is interdisciplinary in nature, involving the application of engineering and mathematics to the solution of problems related to medicine and biology. The faculty reflect this interdisciplinary nature in their courses and research. MU faculty are synergistically complemented by faculty from the MCW. The Department of Biomedical Engineering fosters collaborative interactions between the two institutions. Research can be characterized by the general areas of bioinstrumentation, biomechanics, biomedical imaging, cellular and molecular engineering, computational biology and bioinformatics, and rehabilitation bioengineering.

Prerequisites for Admission

Students with backgrounds in engineering, physical science and life science disciplines are eligible for admission to the master of science, master of engineering, doctoral, and M.D./Ph.D. programs in biomedical engineering. A baccalaureate degree in an appropriate area with a minimum grade point average of 3.000 is required. Applicants who do not have an engineering degree must complete prerequisite engineering requirements. For each degree, the list of prerequisites can be found in the degree’s handbook. See the department webpage for links to the handbooks.

Application Requirements

Applicants must submit, directly to the Marquette University (MU) Graduate School for M.S. and M.E. degree programs or to Medical College of Wisconsin (MCW) Graduate School for the Ph.D. and M.D./Ph.D. degree programs:

  1. A completed online application form and fee.
  2. Copies of all college/university transcripts.1
  3. Three letters of recommendation.
  4. GRE scores (General Test only).
  5. A brief statement of purpose that includes the proposed area of research specialization.
  6. (For M.E. applicants only) an interview with the M.E. program director.
  7. (For international applicants only) a TOEFL score or other acceptable proof of English proficiency.

General Information

All admitted students are required to obtain and read the department’s Graduate Student Handbooks for each of the degree programs, which contains complete details about the biomedical engineering programs. The handbook for each degree is available through the Department of Biomedical Engineering website.

 

Biomedical Engineering Master of Science (M.S.)

Specializations: Bioinstrumentation/Computers, Biomechanics/Biomaterials, Rehabilitation Bioengineering, Systems Physiology

Upon enrolling in the Joint Marquette University/Medical College of Wisconsin Department's master of science (M.S.) program in biomedical engineering, a student selects one of four specializations. Faculty will design a curriculum and research program to address the specific goals of each student. Programs will include course work in engineering, biology, mathematics and medicine, all of which will be integrated with research laboratory experience.

PROGRAM REQUIREMENTS

Academic requirements for the master of science are the following:

  • A total of 30 graduate credit hours, consisting of 24 credit hours of course work and 6 credit hours of BIEN 6999 Master's Thesis.
  • At least 9 credits of course work must be taken at the 6000-level or above (6 credits of which must be in BIEN, exclusive of BIEN 6995 Independent Study in Biomedical Engineering).
  • A minimum of 12 hours of course work must be taken in Biomedical Engineering, exclusive of 3 credits of BIEN 6995 Independent Study in Biomedical Engineering).
  • A minimum of 3 credits (up to 6 credits) in physiology. This requirement is waived for any student who has successfully completed BIEN 5700 Systems Physiology or equivalent. 
  • The remaining courses must be selected from among those that are eligible for graduate credit in science and engineering programs. Up to 3 credits from certain health care courses may be counted. They include HCTM 6200 Health Care Technology Assessment (3 credits), HCTM 6946 Medical College of Wisconsin/HCTM-Joint Degree (Biomedical Technology Standards and Regulations – 2 credits), HCTM 6400 Ethics of Technology Utilization (1.5 credits), HCTM 6500 Management of Medical Product Development (2 credits) and HEAL 6840 The Environment of Health Care Delivery (2 credits).
  • Each master's degree student must submit an outline of the proposed thesis on an Outline for Dissertation, Thesis, Professional Project or Essay form for approval by the thesis director, the director of graduate studies, and the dean of the Graduate School. An acceptable master's degree thesis must meet each of the following four conditions:
    1. The thesis must reflect the student's originality, creativity, and imaginative work.
    2. The thesis must demonstrate the student's research ability. This includes (a) a critical analysis of the relevant literature and (b) an engineering contribution to the state of the art or originality in problem solving. 
    3. The thesis must be well written and professionally presented.
    4. The format of the thesis must follow the Thesis Directives issued by the Graduate School.
  • In addition to completing the thesis, students in the M.S. degree program are required to pass an oral comprehensive examination as part of their thesis defense.
  • Students are also required to register for the Department seminar series each term for the duration of their study (BIEN 6953 Seminar in Biomedical Engineering).

SPECIALIZATIONS

Each student selects one the specializations offered and follows the recommended curriculum for that specialization. Students work with their advisers to choose their didactic course work and develop their tailored Master’s Program Planning Form, carefully following the academic requirements outlined above. 

Specialization-specific course work as determined with adviser24
BIEN 6999Master's Thesis6
Total Credit Hours:30

ACCELERATED BACHELOR’S-MASTER’S DEGREE PROGRAM

This program allows Marquette University students to earn both their master of science degree in biomedical engineering and a bachelor of science degree in five years. Students currently enrolled in the undergraduate biomedical engineering program at Marquette University (with a GPA of 3.500 or above) may apply for admission to the five-year program during their junior year. Students must submit an application to the Graduate School, indicate their interest in the five-year program and meet all other admission criteria as stated in the Application Requirements section. (GRE test scores must be submitted before the start of the fifth year.)

Students may take master’s level courses in their senior undergraduate year. These graduate courses count toward both the undergraduate and graduate degrees. The remaining courses are taken during the students’ fifth year. Work on the students’ theses research begins the summer between the junior and senior years. Students will continue to gain research laboratory experience the summer between the senior and fifth year, continuing through the final year, culminating in preparation of a written thesis and defense. Upon completion of the first term as master’s candidates, students must petition the Graduate School to transfer courses taken as undergraduates to the master’s degree.

 

Biomedical Engineering Master of Engineering (M.E.)

Specializations: Biocomputing, Bioimaging, Bioinstrumentation, Biomechanics, Biorehabilitation

Upon enrolling in the Joint Marquette University/Medical College of Wisconsin Department's master of engineering (M.E.) program in biomedical engineering, a student selects one of five specializations and follows the curriculum designed for that specialization. The program includes course work in engineering, life sciences, mathematics, medicine and healthcare technologies management, all of which will be integrated in a capstone comprehensive written exam. 

Program Requirements

Academic requirements for the master of engineering are the following:

  • A total of 30 credit hours of graduate-level courses and approved upper-division undergraduate courses. 
  • A minimum of 15 credit hours must be BIEN (Biomedical Engineering) courses.
  • Up to 12 credits of upper-division undergraduate courses that carry graduate credit may be taken with permission of the BIEN director of graduate studies.
  • Up to 6 credit hours may be taken in HCTM (Healthcare Technologies Management) courses.
  • Up to two graduate-level courses may be taken outside of the BIEN Department area with permission of the BIEN director of graduate studies.
  • One Readings course:  A faculty member will determine the title and topic, which should link various areas of biomedical engineering. This requirement can be managed via the existing BIEN 6995 Independent Study in Biomedical Engineering/Independent Readings and Research course.
  • Capstone comprehensive written examination.
  • Students are also required to register for the Department seminar series each term for the duration of their study (BIEN 6953 Seminar in Biomedical Engineering). 

Specializations

Each student selects one the specializations offered and follows the recommended curriculum for that specialization. Students work with their advisers to choose their didactic course work and develop their tailored Master’s Program Planning Form.

Biocomputing

Recommended course work:
BIEN 5700Systems Physiology (or equivalent)3
BIEN 5320Biomedical Instrumentation Design3
Graduate electives as approved by adviser (BIEN, MATH, etc., as appropriate)6
BIEN 5220Embedded Biomedical Instrumentation3
HCTM elective as approved by adviser3
BIEN 6300Biomedical Instrumentation3
BIEN Biocomputer elective as approved by adviser3
BIEN 6200Biomedical Signal Processing3
BIEN 6995Independent Study in Biomedical Engineering (Required Readings course)3
Total Credit Hours:30

Bioimaging

Recommended course work:
BIEN 5700Systems Physiology (or equivalent)3
BIEN 5320Biomedical Instrumentation Design3
Graduate electives as approved by adviser (BIEN, MATH, etc., as appropriate)6
BIEN 5500Medical Imaging Physics3
HCTM elective as approved by adviser3
BIEN 6210Advanced Biomedical Signal Processing3
BIEN Bioimaging elective as approved by adviser3
BIEN 6220Multidimensional Biomedical Time Series Analysis3
BIEN 6995Independent Study in Biomedical Engineering (Required Readings course)3
Total Credit Hours:30

Bioinstrumentation

Recommended course work:
BIEN 5700Systems Physiology (or equivalent)3
BIEN 5320Biomedical Instrumentation Design3
Graduate electives as approved by adviser (BIEN, MATH, etc., as appropriate)6
BIEN 5220Embedded Biomedical Instrumentation3
HCTM elective as approved by adviser3
BIEN 6310Microprocessor Based Biomedical Instrumentation3
BIEN Bioinstrumentation elective as approved by adviser
BIEN 6320Radio Frequency Applications in Biomedical Engineering3
BIEN 6995Independent Study in Biomedical Engineering (Required Readings course)3
Total Credit Hours:27

Biomechanics

Recommended course work:
BIEN 5700Systems Physiology (or equivalent)3
BIEN 5320Biomedical Instrumentation Design3
Graduate electives as approved by adviser (BIEN, MATH, etc., as appropriate)6
BIEN 5710Analysis of Physiological Models3
HCTM elective as approved by adviser3
BIEN 6450Musculoskeletal Biomechanics 13
BIEN Biomechanics elective as approved by adviser3
BIEN 6451Musculoskeletal Biomechanics 23
BIEN 6995Independent Study in Biomedical Engineering (Required Readings course)3
Total Credit Hours:30

Biorehabilitation

Recommended course work:
BIEN 5700Systems Physiology (or equivalent)3
BIEN 5320Biomedical Instrumentation Design3
Graduate electives as approved by adviser (BIEN, MATH, etc., as appropriate)6
BIEN 5710Analysis of Physiological Models3
HCTM elective as approved by adviser3
BIEN 6610Rehabilitative Biosystems3
BIEN Biorehabilitation elective as approved by adviser3
BIEN 6620Modeling Rehabilitative Biosystems3
BIEN 6995Independent Study in Biomedical Engineering (Required Readings course)3
Total Credit Hours:30

Biomedical Engineering Doctorate

Specializations: Bioinstrumentation, Biomechanics, Biomedical Imaging, Cellular and Molecular Engineering, Computational Biology and Bioinformatics, Rehabilitation Bioengineering

Upon enrolling in the doctoral (Ph.D.) program in biomedical engineering, a student selects their area of specialization. Faculty design a curriculum and research program to address the specific goals of each student. Programs include course work in engineering, biology, mathematics and medicine, all of which are integrated with research laboratory experience.

The Ph.D. degree is conferred in recognition of marked ability and high attainment in the advancement of knowledge and pursuit of truth. The comprehensive knowledge expected of the student in their major field is such that the requirements for the degree usually take no less than four years of full-time work, or the equivalent, beyond the baccalaureate degree.

A doctoral student must complete a program of study prepared in consultation with their dissertation adviser and outlined on an approved Doctoral Program Planning Form. The student also must pass a doctoral qualifying examination (DQE) and submit and successfully defend a dissertation.

Students in the Medical Scientist Training Program (MSTP; a combined M.D./Ph.D. degree program) at MCW are eligible to choose the Ph.D. program of the joint MU-MCW Department of Biomedical Engineering for the Ph.D. requirements of the M.D./Ph.D. degree program.

MSTP students begin their curriculum at MCW with two full years of medical school (M1 and M2 years), during which they complete a large array of clinical, translational and basic science course work, equivalent to a master of science degree. During their M1 and M2 years, they also complete four one-month long laboratory rotations during which they gain valuable research experience. These lab rotations are intended to help MSTP students to choose a lab and a research area (by the end of their M2 year) for conducting their Ph.D. dissertation research. Following their M1 and M2 years, MSTP students typically spend three to four years in graduate school, working toward their doctoral dissertation before returning to the medical school to complete their medical training. 

The Doctoral Candidacy Examination consists of two parts. The first part involves writing a dissertation proposal in the form of an NIH-style F30/F31 fellowship grant proposal and submitting it to the student’s Dissertation Committee. The second part is an oral examination, involving the student’s presentation and defense of the dissertation proposal, in which the Dissertation Committee members serve as examiners. The student must submit a dissertation proposal and pass the oral examination to advance to doctoral candidacy. 

Students entering the Ph.D. program with a bachelor of science degree are encouraged to take the DQE at or before the completion of 30 graduate credits of didactic course work. MSTP students and students entering the Ph.D. program with a master of science degree are encouraged to take the DQE at or before the completion of 15 graduate credits of didactic course work. Given the time constraints to which MSTP students must adhere, they are strongly advised to take the DQE and advance to doctoral candidacy by the end of their first year in the biomedical engineering doctoral program.

The dissertation must represent an original research contribution showing high attainment and clear ability to do independent research. A public defense of the dissertation (the final oral examination) is conducted after the student has completed all other formal requirements for the doctoral degree and has submitted a completed doctoral dissertation to his or her doctoral committee. The dissertation defense is conducted in the form of a department seminar.

Program Requirements

A minimum of 60 graduate credits are required to complete the Ph.D. degree in biomedical engineering. Prerequisite courses for applicants who do not have a biomedical engineering degree are not counted as graduate credits.

Reading and research credits can be earned by registering and attending a seminar series, workshop, conference, journal club or simply carrying dissertation-related activities. A student can register for up to 9 credits of reading and research per term during fall and spring terms and up to 6 credits during the summer. Students should register for dissertation credits in the term they intend to defend their dissertation.

Didactic Course Work

Students may choose their didactic course work from the following options under each category and must work with their adviser to develop their tailored Doctoral Program Planning Form.

Systems Physiology3
Exercise Physiology
Cardiopulmonary Mechanics
Topics in Biomedical Engineering
Physiol 08204 1
Biostatistical Methods3
Statistical Methods
Biostatistical Methods and Models
Biostat 04224 1
Biostat 04231 1
Biostat 04232 1
Biomedical Signal Processing3
Image Processing for the Biomedical Sciences
Biomedical Signal Processing
Advanced Biomedical Signal Processing
Multidimensional Biomedical Time Series Analysis
Biophys 03240 1
Bioethics2
Bioethics 10222 1
Bioethics 10444 1
Advanced Engineering Mathematics3
Mathematics of Medical Imaging
Advanced Engineering Mathematics
Advanced Engineering Analysis 1
Computational and Simulation Methods3
Analysis of Physiological Models
Modeling Rehabilitative Biosystems
Physiol 08284 1
Physiol 08285 1
Specialization specific courses; selected in consultation with the student's dissertation director19

Post-Baccalaureate Program of Study

Those entering with a bachelor of science degree, are required to complete 36 credits in didactic course work, 9 credits in dissertation, and a minimum of 15 credits in reading and research.

Didactic Course Work36
Doctoral Dissertation Credits9
Reading and Research Credits15
Total Credit Hours:60

Post-Master's Program of Study

Those entering with a master of science degree or with graduate credits (see Transfer of Credit policy), are required to complete a minimum of 18 credits in didactic course work, 9 credits in dissertation, and a minimum of 33 credits in reading and research.

Didactic Course Work18
Doctoral Dissertation Credits9
Reading and Research Credits33
Total Credit Hours:60

Doctoral students in the Biomedical Engineering Department are also required to register for the Department seminar series each term for the duration of their study (BIEN 6953 Seminar in Biomedical Engineering). For a given term, students are expected to attend at least two-thirds of the seminars. 

The Doctoral Program Planning Form should include a list of the courses that the student intends to take to satisfy the core course requirements.

Courses

BIEN 5220. Embedded Biomedical Instrumentation. 3 cr. hrs.

Fundamentals of digital circuit design and analysis and the application to embedded biomedical instrumentation. Topics include microprocessor principles and programming and system design constraints for medical electronics. Laboratory provides applications of concepts introduced in class.

BIEN 5230. Intelligent Biosystems. 3 cr. hrs.

Use of emerging tools in systems biology and soft computing to explore how biosystems with highly distributed "intelligence" are designed to adapt to self- and environmentally-induced perturbations. Students obtain a basic understanding of key soft computing tools and use fuzzy expert system models. Applications to smart healthcare monitoring and future product design will be explored. Prereq: BIEN 4700/5700.

BIEN 5320. Biomedical Instrumentation Design. 3 cr. hrs.

Fundamental knowledge and skills needed to solve instrumentation problems relating to biomedical and physiological measurements in the laboratory and clinic. Key elements include biosignals, signal conditioning, sensors and transducers, data acquisition, instrument design and safety requirements. Includes hands-on experiences in basic instrumentation lab skills, needs identification, design, implementation, testing and troubleshooting, and report writing.

BIEN 5400. Transport Phenomena. 3 cr. hrs.

Applications of mass, momentum, and mechanical energy balances to biomedical fluid systems. Study of physiological phenomena with an emphasis on cardiovascular systems and blood rheology.

BIEN 5410. Applied Finite Element Analysis. 3 cr. hrs.

Introduces the finite element solution method for linear, static problems. Includes calculation of element stiffness matrices, assembly of global stiffness matrices, exposure to various finite element solution methods, and numerical integration. Emphasizes structural mechanics, and also discusses heat transfer and fluid mechanics applications in finite element analysis. Computer assignments include development of finite element code (FORTRAN or C) and also use of commercial finite element software (ANSYS and/or MARC).

BIEN 5420. Biomaterials Science and Engineering. 3 cr. hrs.

Designed to introduce the uses of materials in the human body for the purposes of healing, correcting deformities and restoring lost function. The science aspect of the course encompasses topics including: characterization of material properties, biocompatibility and past and current uses of materials for novel devices that are both biocompatible and functional for the life of the implanted device. Projects allow students to focus and gain knowledge in an area of biomaterials engineering in which they are interested. Prereq: MEEN 2460 or cons. of instr.

BIEN 5500. Medical Imaging Physics. 3 cr. hrs.

Examines how light, X-rays, radiopharmaceuticals, ultrasound, magnetic fields, and other energy probes are generated and how they interact with tissues and detectors to produce useful image contrast. Addresses practical issues such as beam generation, dose limitations, patient motion, spatial resolution and dynamic range limitations, and cost-effectiveness. Emphasizes diagnostic radiological imaging physics, including the planar X-ray, digital subtraction angiography mammography, computed tomography, nuclear medicine, ultrasound, and magnetic resonance imaging modalities.

BIEN 5510. Image Processing for the Biomedical Sciences. 3 cr. hrs.

Introduces biomedical image processing. Topics explored include: the human visual system, spatial sampling and digitization, image transforms, spatial filtering, Fourier analysis, image enhancement and restoration, nonlinear and adaptive filters, color image processing, geometrical operations and morphological filtering, image coding and compression image segmentation, feature extraction and object classification. Applications in diagnostic medicine, biology and biomedical research are emphasized and presented as illustrative examples.

BIEN 5600. Neural Engineering. 3 cr. hrs.

Basic principles of neural engineering, properties of excitable tissues, quantitative models used to examine the mechanisms of natural and artificial stimulation. Basic concepts for the design of neuroprosthetic devices for sensory, motor and therapeutic applications. Design issues including electrode type, biomaterials, tissue response to stimulating electrodes and stimulus parameters for electrical stimulation and artificial control. Examples of how engineering interfaces with neural tissue show increasing promise in the rehabilitation of individuals of neural impairment.

BIEN 5610. Introduction to Rehabilitation Robotics. 3 cr. hrs.

Presents the fundamentals of robotics as it is applied to rehabilitation engineering. Specific topics include: the fundamentals of analysis and design of robot manipulators with examples and mini-projects taken from rehabilitation applications pertaining to robotic therapy devices and personal assistants. Additional topics include: overview of rehabilitation robotics field, human-centered design of rehabilitation robots issues and challenges, robot configurations, rigid motions and homogeneous transformations, Denavit-Hartenberg representation, robot kinematics, and inverse kinematics, Euler-Lagrange equations, trajectory generation, sensors, actuators, independent joint control, force control and safety.

BIEN 5620. Rehabilitation Engineering: Telerehabilitation Research Tools. 3 cr. hrs.

Introduces rehabilitation science as the study of tissue and functional change, including: overview of key human sensory modalities and neuromotor systems in the context of functional capabilities and human performance metrics; review of spontaneous recovery mechanisms in response to various types of tissue trauma; review of roles of genetics and gene transcription networks in pathology and functional recovery prognosis; and the concept of rehabilitative assessment and therapeutic interventions as an optimization problem. Also focuses on the use of assistive technology to enhance access to independent living and to optimize the delivery of rehabilitative healthcare services. Includes rehabilitation biomechanics of physical interfaces, use of access and usability engineering in product design and innovative assessment and intervention strategies for neurorehabilitation.

BIEN 5630. Rehabilitation Engineering: Prosthetics, Orthotics, Seating and Positioning. 3 cr. hrs.

Presents an overview of biomedical engineering as it applies to Rehabilitation Engineering, specifically, the design and prescription of prosthetic limbs, orthotic devices, and seating and positioning systems. Topics include medical terminology, musculoskeletal anatomy, muscle mechanics, soft tissue mechanics, gait/locomotion, amputation surgery, lower extremity prosthetics, lower extremity orthotics, hand function, electromyography, upper extremity prosthetics, upper extremity orthotics, seating and positioning and assistive devices.

BIEN 5640. Bioengineering of Living Actuators. 3 cr. hrs.

Overview of muscle tissue as a living actuator from the perspective of engineering design, systems biology, muscle modeling and adaptive control. Prereq: BIEN 4700/5700.

BIEN 5700. Systems Physiology. 3 cr. hrs.

Analyses of the underlying physiologic and bioengineering aspects of the major cell and organ systems of the human from an engineer's point of view. Classic physiologic approaches used to introduce topics including cell functions, nervous system, nerve, muscle, heart, circulation, respiratory system, kidney, reproduction and biomechanics. Design problems including models of cell-organ-system function and problems in biomechanics illuminate topics covered. Computer techniques and relevant instrumentation are incorporated. Experts on related topics are invited to speak as they are available.

BIEN 5710. Analysis of Physiological Models. 3 cr. hrs.

Development of continuous (compartmental) and distributed-in-space-and-time mathematical models of physiological systems and molecular events. Analytical and numerical methods for solving differential equations of the initial and boundary value types. Simulation of model response, and estimation of model parameters using linear and nonlinear regression analysis.

BIEN 5720. Cardiopulmonary Mechanics. 3 cr. hrs.

Examination of the physiological behavior of the cardiovascular and pulmonary systems from an engineering perspective. Emphasis is on understanding the mechanical basis of physiologic phenomena via experimental models.

BIEN 5931. Topics in Biomedical Engineering. 1-3 cr. hrs.

Course content announced prior to each term. Students may enroll in the course more than once as subject matter changes. Possible topics include biomechanics, experimental methods, neuroanatomy, telemetry, etc.

BIEN 6120. Introduction to the Finite Element Method. 3 cr. hrs.

Introduces finite element analysis as applied to linear, static problems. Application to problems in plane strain, plane stress, and axisymmetry. Development of shape functions and element stiffness matrices. Although primarily structural analysis, also considers problems in heat transfer and fluid mechanics. Use of user-written and packaged software. Prereq: GEEN 2130; and matrix/linear algebra or equiv.

BIEN 6121. Applied Finite Element Analysis and Modeling. 3 cr. hrs.

Advanced finite element analysis as applied to nonlinear (both material and geometric nonlinearities), dynamic problems. Use of penalty methods and perturbed Lagrangian methods. Use of user-written and packaged software. Critical reviews of finite element analysis in biomechanical research. Prereq: BIEN 6120; or CEEN 6120 or equiv.

BIEN 6200. Biomedical Signal Processing. 3 cr. hrs.

Introduces students to statistical processing of biomedical data. Topics include: data acquisition, probability and estimation, signal averaging, power spectrum analysis, windowing, digital filters and data compression. Students complete several computer projects which apply these processing methods to physiologic signals. Prereq: MATH 2451; and proficiency in C or FORTRAN.

BIEN 6210. Advanced Biomedical Signal Processing. 3 cr. hrs.

Covers modern methods of signal processing encountered in the bio-medical field including parametric modeling, modern spectral estimation, multivariate analysis, adaptive signal processing, decimation/interpolation, and two-dimensional signal analysis. Students complete several computer projects which apply these modern techniques to physiologic data. Prereq: BIEN 6200 or equiv.; knowledge of C or FORTRAN.

BIEN 6220. Multidimensional Biomedical Time Series Analysis. 3 cr. hrs.

Theory and implementation of methods used to collect, model and analyze multidimensional time series encountered in biomedical applications such as functional imaging, electrophysiologic mapping and the study of physiologic control systems. Prereq: BIEN 6200; proficiency in C or FORTRAN.

BIEN 6300. Biomedical Instrumentation. 3 cr. hrs.

Explores relationships between instruments for physiologic measurement and monitoring with living systems. Physiologic signals, noise, and available sensors and transducers and their characteristics are discussed from time and frequency domain points of view. Systems topics include various new and conventional medical instrumentation. Other topics include clinical and new clinical laboratory instrumentation, instrumentation for research, artificial organs and prostheses. Includes the use of scientific literature, literature searches, design projects, computer projects. Prereq: BIEN 5700; or BIEN 5320; and high level computer language or equiv.

BIEN 6310. Microprocessor Based Biomedical Instrumentation. 3 cr. hrs.

Discusses the application of microprocessors, microcontrollers, and digital signal processors to biomedical instrumentation. Complements BIEN 6300, which covers transducers, sensors, analog signal conditioning, and analog to digital conversion. Emphasizes evaluating the memory, power, resolution, cost, and computational requirements of a particular application, and then selecting a type (microprocessor, microcontroller, or digital signal processor) and particular model of processor to satisfy the system requirements. Students design at least two complete processor based systems. Prereq: Knowledge of digital electronics and microprocessors.

BIEN 6320. Radio Frequency Applications in Biomedical Engineering. 3 cr. hrs.

Radio frequency design and applications for biomedical engineering and medicine. Circuit elements, equivalent circuits, impedance transformations, Smith Chart, two ports, scattering parameters, amplifiers, resonant circuits, mixers, receivers. Applications include telemetry, transcutaneous power transfer, hyperthermia, rf ablation, magnetic resonance imaging; HP-EESOF LIBRA and Ascent CAD are introduced as analysis and design tools. Guest speakers. Written and oral design reports. Prereq: Undergraduate background in circuit theory and analog electronics.

BIEN 6400. Biofluid Mechanics. 3 cr. hrs.

Development of the theory of fluid mechanics as applied to living systems. Considers both steady and unsteady flows of Newtonian and non-Newtonian fluids. Topics include: viscometry, blood flow, gas and aerosolflows, pulsatile flow and wave propagation and applications to the understanding of flows in organs and to the measurement of blood pressure and flow. Prereq: BIEN 4400 or equiv.; or MEEN 3320 or CEEN 3150.

BIEN 6410. Biological Mass Transfer. 3 cr. hrs.

Development of the theory of mass transfer. Fick's law and free diffusion. Osmosis, facilitated diffusion, active transport, transport across cell membranes and applications to cell biology and organ physiology.

BIEN 6420. Biomechanical and Biomaterial Systems Analysis. 3 cr. hrs.

Using fundamentals of biomaterials engineering and biocompatibility, analyzes the functions that organs serve and to analyze the efficacy and safety of artificial organs systems. Some organs/tissues discussed include the kidneys, liver, skeleton, skin, heart, muscles, eyes, and ears. Critically examines the suitability of state-of-the-art artificial organ systems, including artificial hearts, orthopaedic prostheses, kidney dialyzers, and cochlear devices to fulfill the functions of the replaced organs/tissues. Prereq: BIEN 5420.

BIEN 6440. Biomedical Engineering Analysis of Trauma. 3 cr. hrs.

An engineering analysis of the physiological changes following impact to the head, spinal cord, and limbs, and electrical events and effects on tissues are treated.

BIEN 6450. Musculoskeletal Biomechanics 1. 3 cr. hrs.

Emphasizes the interrelationship of force and motion as related to anatomic structure and function. Examines the forces and motions acting in the skeletal system and the various techniques used to describe them. Highlights current concepts as revealed in the recent scientific and engineering literature. Topics include: bone mechanics, joint mechanics, gait kinematics, instrumentation and measurement of biomechanical phenomena, and computer modeling of the musculoskeletal system. Prereq: GEEN 2120 and GEEN 2130.

BIEN 6451. Musculoskeletal Biomechanics 2. 3 cr. hrs.

Advanced concepts of kinematics and mechanics as they apply to the fields of biomechanics and rehabilitation. Covers aspects of gait, bone and joint surgery, and soft tissue surgery. Detailed study of joint mechanics, implant applications and mobility device function is performed. Includes advanced analysis and modeling as well as laboratory-based final project. Prereq: BIEN 6450.

BIEN 6470. Biomechanics of the Spine. 3 cr. hrs.

Analyzes anatomical and functional relationships among the hard and soft tissue structures of the spine as a function of vertebral column development, aging, disease and trauma. Emphasis given to the mechanisms of external and internal load transfer. Imaging (e.g. CT), experimental and finite element methods are used to study the effects of physiologic/traumatic loading, surgery and spinal disorders. Discusses current advancements in biomechanical/clinical literature.

BIEN 6500. Mathematics of Medical Imaging. 3 cr. hrs.

Begins with an overview of the application of linear systems theory to radiographic imaging (pinhole imaging, transmission and emission tomography), and covers the mathematics of computed tomography including the analytic theory of reconstructing from projections and extensions to emission computed tomography and magnetic resonance imaging. Topics may also include three-dimensional imaging, noise analysis and image quality, and optimization. Contains advanced mathematical content.

BIEN 6600. Neuromotor Control. 3 cr. hrs.

Overview of current issues in neuromotor control and movement biomechanics. Special emphasis on the study of normal and impaired human movement. Topics include: muscle mechanics, biomechanics of movement, neural circuitry, strategies for the neural control of movement (including a discussion of adaptation and motor learning) and potential applications of biomedical engineering techniques to the study and improvement of impaired motor function. Prereq: BIEN 3300 which may be taken concurrently or equiv.; or cons. of instr.

BIEN 6610. Rehabilitative Biosystems. 3 cr. hrs.

Examines the plastic changes in biological systems that occur in response to targeted stimuli. These processes involve responses by cells to chemical, mechanical, or electrical stimuli (which may be related), which may be influenced or directed using engineering techniques. Examines the homeostasis of physiologic systems and their response to pathologic and rehabilitative stimuli. Examines engineering applications involving the diagnosis and rehabilitation of musculoskeletal, neurologic and cardiopulmonary biosystems in the context of the underlying cellular mechanisms. Prereq: BIEN 5700 which may be taken concurrently; and PHYS 1004.

BIEN 6620. Modeling Rehabilitative Biosystems. 3 cr. hrs.

Introduction to large-scale mathematical models of various physiological systems of interest in rehabilitation (e.g., cardiovascular, pulmonary, musculoskeletal, etc.). Discusses mathematical modeling, a widely used tool for testing hypotheses regarding the underlying mechanisms of complex systems such as physiological systems in health, disease and recovery. For each, simulation is used to further our understanding of the adaptive processes of these systems in response to physiological/pathophysiological stresses and rehabilitative interventions. Prereq: BIEN 5710 and BIEN 5700.

BIEN 6700. Analysis of Physiological Systems. 3 cr. hrs.

Introduction to the use of mathematical models in quantifying physiological systems. Analyzes model formulation. Applications of analytical and numerical solution techniques and parameter estimation methods. Prereq: BIEN 5710.

BIEN 6710. Cellular and Molecular Bioengineering. 3 cr. hrs.

Main topics include: cellular biomechanics with an emphasis on the cardiovascular system, molecular bioengineering, biotransport phenomena, and tissue engineering with focus on artificial internal organs. Cellular biomechanics topics covered are biomechanics of the endothelium, endothelial-immune cell interactions, and blood cell structural biomechanics. Topics in molecular bioengineering include chemotaxis and chemokinesis, and modeling of receptor-mediated endocytosis. Biotransport and tissue engineering topics include bioreactor design and the analysis and development of artificial internal organs like the liver and pancreas.

BIEN 6931. Topics in Biomedical Engineering. 3 cr. hrs.

Subject matter variable as determined by needs of biomedical graduate students. Students may enroll more than once as the subject matter changes. Possible topics: biostatistics, experimental methods, neuro-anatomy, etc.

BIEN 6932. Advanced Topics in Biomedical Engineering. 3 cr. hrs.

Advanced topics in design and analysis of biomedical instruments, devices and interfaces. Project approach drawing from current literature and current projects of laboratories of affiliated institutions. Topics include bioelectronics, biomechanics, biomaterials, and rehabilitation engineering.

BIEN 6947. Medical College of Wisconsin/Joint Degree. 1-8 cr. hrs.

Graduate-level course in selected areas of the life sciences offered at the Medical College of Wisconsin. May be taken by doctorate BIEN students at Marquette University. Prereq: Cons. of dept. ch.

BIEN 6953. Seminar in Biomedical Engineering. 0 cr. hrs.

Scholarly presentations on current topics in biomedical engineering and related areas by visiting professors, resident faculty and graduate students. Attendance is required of all full-time graduate students. SNC/UNC grade assessment. Mandatory for all full-time BIEN graduate students.

BIEN 6954. Seminar in Biomedical Computing. 0 cr. hrs.

Scholarly presentations on current topics in biomedical engineering and related areas by visiting professors, resident faculty and graduate students. Attendance is required of all full-time graduate students. SNC/UNC grade assessment. Mandatory for all full-time BIEN graduate students.

BIEN 6960. Seminar: Journal Club. 3 cr. hrs.

0 credit will be SNC/UNC grade assessment; 1-3 credits will be graded.

BIEN 6995. Independent Study in Biomedical Engineering. 1-3 cr. hrs.

Faculty-supervised, independent study/research of a specific area or topic in Biomedical Engineering. Prereq: Cons. of instr. and cons. of dept. ch.

BIEN 6999. Master's Thesis. 1-6 cr. hrs.

S/U grade assessment. Prereq: Cons. of instr.

BIEN 8110. Research Methodologies 1. 3 cr. hrs.

Development of research aims and hypotheses, identification of relevant scientific literature, experimental approaches, statistical design, and pilot work to obtain preliminary results. Emphasizes written communication of research theme. The course project consists of the development of a research proposal including research aims, background, pilot experiments, and experimental design and methodology. Prereq: Accepted Ph.D. student in biomedical engineering.

BIEN 8120. Research Methodologies 2. 3 cr. hrs.

Oral and written communication of research results including graphics and text. Addresses graphical presentation of data and conceptual development of a scientific presentation and a manuscript. Emphasizes the basics of clear and effective scientific communication. Work culminates in the development of a scientific manuscript for peer review. Prereq: Accepted Ph.D. student in biomedical engineering.

BIEN 8210. Teaching Methodologies. 3 cr. hrs.

Seminar aimed at issues important for teaching in a university setting. Topics include: development of teaching philosophy, planning a class, designing a syllabus, assessing student learning and using technology in the classroom. Taught in conjunction with the Preparing Future Faculty (PFF) program. Prereq: Accepted Ph.D. student in biomedical engineering.

BIEN 8995. Independent Study in Biomedical Engineering. 1-3 cr. hrs.

In-depth research on a topic or subject matter usually not offered in the established curriculum with faculty and independent of the classroom setting. Prereq: Cons. of instr. and cons. of dept. ch.

BIEN 8999. Doctoral Dissertation. 1-12 cr. hrs.

S/U grade assessment. Prereq: Cons. of instr.

BIEN 9970. Graduate Standing Continuation: Less than Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Designated as less than half-time status only, cannot be used in conjunction with other courses, and does not qualify students for financial aid or loan deferment. Prereq: Cons. of dept. ch.

BIEN 9974. Graduate Fellowship: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Designated as full-time status. If a student is already registered in other courses full time, this continuation course is not needed. Prereq: Cons. of dept. ch.

BIEN 9975. Graduate Assistant Teaching: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Designated as full-time status. If a student is already registered in other courses full time, this continuation course is not needed. Prereq: Cons. of dept. ch.

BIEN 9976. Graduate Assistant Research: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Designated as full-time status. If a student is already registered in other courses full time, this continuation course is not needed. Prereq: Cons. of dept. ch.

BIEN 9984. Master's Comprehensive Examination Preparation: Less than Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of less than half-time status. Requires that the student is working less than 12 hours per week toward their master's comprehensive exam. Prereq: Cons. of dept. ch.

BIEN 9985. Master's Comprehensive Examination Preparation: Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of half-time status. Requires that the student is working more than 12 to less than 20 hours per week toward their master's comprehensive exam. May be taken in conjunction with credit-bearing or other non-credit courses to result in the status indicated, as deemed appropriate by the department. Prereq: Cons. of dept. ch.

BIEN 9986. Master's Comprehensive Examination Preparation: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of full-time status. Requires that the student is working 20 hours or more per week toward their master's comprehensive exam. May be taken in conjunction with credit-bearing or other non-credit courses to result in the status indicated, as deemed appropriate by the department. Prereq: Cons. of dept. ch.

BIEN 9987. Doctoral Qualifying Examination Preparation: Less than Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of less than half-time status. Requires that the student is working less than 12 hours per week toward their doctoral qualifying exam. Prereq: Cons. of dept. ch.

BIEN 9988. Doctoral Qualifying Examination Preparation: Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of half-time status. Requires that the student is working more than 12 to less than 20 hours per week toward their doctoral qualifying exam. May be taken in conjunction with credit-bearing or other non-credit courses to result in the status indicated, as deemed appropriate by the department. Prereq: Cons. of dept. ch.

BIEN 9989. Doctoral Qualifying Examination Preparation: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of full-time status. Requires that the student is working 20 hours or more per week toward their doctoral qualifying exam. May be taken in conjunction with credit-bearing or other non-credit courses to result in the status indicated, as deemed appropriate by the department. Prereq: Cons. of dept. ch.

BIEN 9991. Professional Project Continuation: Less than Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of less than half-time status. Requires that the student is working less than 12 hours per week on their professional project. Any professional project credits required for the degree should be completed before registering for non-credit Professional Project Continuation. Prereq: Cons. of dept. ch.

BIEN 9992. Professional Project Continuation: Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of half-time status. Requires that the student is working more than 12 to less than 20 hours per week on their professional project. Any project credits required for the degree should be completed before registering for non-credit Professional Project Continuation. Prereq: Cons. of dept. ch.

BIEN 9993. Professional Project Continuation: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of full-time status. Requires that the student is working 20 hours or more per week on their professional project. Any professional project credits required for the degree should be completed before registering for non-credit Professional Project Continuation. Prereq: Cons. of dept. ch.

BIEN 9994. Master's Thesis Continuation: Less than Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of less than half-time status. Requires that the student is working less than 12 hours per week on their master's thesis. All six thesis credits required for the degree should be completed before registering for non-credit Master's Thesis Continuation. Prereq: Cons. of dept. ch.

BIEN 9995. Master's Thesis Continuation: Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of half-time status. Requires that the student is working more than 12 to less than 20 hours per week on their master's thesis. All six thesis credits required for the degree should be completed before registering for non-credit Master's Thesis Continuation. Prereq: Cons. of dept. ch.

BIEN 9996. Master's Thesis Continuation: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of full-time status. Requires that the student is working 20 hours or more per week on their master's thesis. All six thesis credits required for the degree should be completed before registering for non-credit Master's Thesis Continuation. Prereq: Cons. of dept. ch.

BIEN 9997. Doctoral Dissertation Continuation: Less than Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of less than half-time status. Requires that the student is working less than 12 hours per week on their doctoral dissertation. All 12 dissertation credits required for the degree should be completed before registering for non-credit Doctoral Dissertation Continuation. Prereq: Cons. of dept. ch.

BIEN 9998. Doctoral Dissertation Continuation: Half-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of half-time status. Requires that the student is working more than 12 to less than 20 hours per week on their doctoral dissertation. All 12 dissertation credits required for the degree should be completed before registering for non-credit Doctoral Dissertation Continuation. Prereq: Cons. of dept. ch.

BIEN 9999. Doctoral Dissertation Continuation: Full-Time. 0 cr. hrs.

Fee. SNC/UNC grade assessment. Allows a student to be considered the equivalent of full-time status. Requires that the student is working 20 hours or more per week on their doctoral dissertation. All 12 dissertation credits required for the degree should be completed before registering for non-credit Doctoral Dissertation Continuation. Prereq: Cons. of dept. ch.