The Opus College of Engineering is made up of four departments which offer the following majors and minors:
- the Department of Biomedical Engineering offers majors in biocomputing, bioelectronics and biomechanics and the minor in biomedical engineering
- the Department of Civil, Construction and Environmental Engineering offers majors in civil engineering, construction engineering, and environmental engineering and minors in civil engineering and environmental engineering
- the Department of Electrical and Computer Engineering offers majors in computer engineering and electrical engineering and minors in computer engineering and electrical engineering
- the Department of Mechanical Engineering offers a major in mechanical engineering and a minor in mechanical engineering
Concentrations in engineering leadership and global engineering are available for all the above engineering majors.
The Opus College of Engineering offers the minor in engineering ethics and values.